Article Abstract:
Chronic phospholamban (PLB)-sarcoplasmic reticulum calcium ATPase interaction is discussed as the critical calcium cycling defect in dilated cardiomyopathy. A study has used a genetic complementation strategy in a well-known mouse model of dilated cardiomyopathy. It is deficient in the cytoskeletal LIM protein, which is muscle-specific. Progressive defects in excitation-contraction coupling are related to enhancement of inhibition of SER-CA2a by PLB. Inhibition of PLB expression or PLB-SERCA2a interaction can prevent heat failure.
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Article Abstract:
Protein disulfide isomerase (PDI) has been found to act as a redox-dependent chaperone in the unfolding of cholera toxin in the endoplasmic reticulum (ER) lumen. This happens after the A chain of the toxin has been cleaved. A role for PDI is suggested in retrograde protein transport into the cytosol, and it can function as a novel type of chaperone. The binding and release of substrates would then be regulated by a redox cycle, not an ATPase cycle.
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Article Abstract:
The endoplasmic reticulum (ER) is one of the most architecturally striking of all eukaryotic organelles, having distinct morphological domains composed of sheets and tubules, which differ in their characteristic membrane curvature. A study finds that key proteins might drive the formation of these structural morphologies, which in turn could generate the rough and smooth functional domains of the ER.
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