Endocrine disruptors signal the need for receptor models and mechanisms to inform policy

Article Abstract:

Endocrine disruptors, a group of environmental agents that mimic or interfere with the functions of endogenous hormones, are raising global concerns due to their potential adverse health effects on humans and animals. Experts were discussing the possibility of using the receptor theory for the development of public policy for risk assessment and prevention. Endocrine disruptors are widely perceived to have the ability to interact with receptors as agonists, antagonists, partial agonists or negative antagonists.

Hormone receptors, Hormones

Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpefat mice

Article Abstract:

A mechanism for sorting secretory proteins into granules for release through the regulated secretory pathway in endocrine-neuroendocrine cells is suggested. The approach involves binding the proteins to a sorting receptor at the trans-Golgi network, proceeded by budding and granule formation. Membrane-associated carboxypeptidase E in pituitary Golgi-enriched and secretory granule membranes is the sorting receptor.

Proteases, Suppression, Genetic, Suppressor mutation (Molecular genetics), Endocrinology

Chromogranin A, an "On/Off"switch controlling dense-core secretory granule biogenesis

Article Abstract:

Research shows that chromogranin A is a key regulator of dense-core secretory granule biogenesis as well as storage of other granule proteins in neuroendocrine cells. Data reveal that down regulation of chromogranin A results in the loss of dense-core secretory granules, hormone secretion, and reducion of secretory granule proteins.

United States, Secretion, Physiological regulation, Neuroendocrinology, Neurohormones