Founder BRCA1 (ital) and BRCA2 (ital) mutations in French Canadian breast and ovarian cancer families
Article Abstract:
Four founder mutations in each of the breast-cancer susceptibility genes in Quebec French Canadian ovarian and breast cancer families are discussed. Independently ascertained cancer families of French Canada were examined for distribution of the eight mutations in BRCA2 (ital) and BRCA2 (ital), and they were found in 41 of 97 families, with six of the eight mutations seen at least twice.
author: Morgan, Kenneth, Narod, Steven A., Ghadirian, Parviz, Provencher, Diane, Futreal, P. Andrew, Foulkes, William D., Tonin, Patricia N., Mes-Masson, Anne-Marie, Cole, David E.C., Mahon, Michelle
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
Statistical Data Included, Gene mutations, Gene mutation, Ovarian cancer, French-Canadians, French speaking Canadians
Linkage analysis of chromosome 1q in 136 prostate cancer families
Article Abstract:
Linkage analysis of chromosome 1q has been carried out in in 136 prostate cancer families with the finding of no significant evidence of linkage to markers on 1q at a locus designated HPC1 (ital). The conclusion is that the HPC1 (ital) locus is the basis for a minority of familial prostate cancer cases. It is likely most important in families with at least four cases.
author: Narod, Steven A., Ghadirian, Parviz, Easton, Douglas, Ardern-Jones, Audrey, Simard, Jacques, Labrie, Fernand, Hamoudi, Rifat, Biggs, Patrick, Ford, Deborah, Edwards, Steve, Foulkes, William D., Eeles, Rosalind A., Durocher, Francine, Teare, Dawn, Badzioch, Mike, Gill, Sandra, Dearnaley, David, Dowe, Anna, Shearer, Robert, McLennan, Dawn L., Norman, Richard L., Aprikian, Armen, Amos, Chris, King, Terri M.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
United Kingdom, United States, Prostate cancer
RAD51 135G C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies
Article Abstract:
The article examines RAD51 135 G C polymorphism (rs1801320) with breast cancer risk among BRCA2 female mutation carriers from 19 studies. RAD51 gene is found to be reliable as a modifier of risk among BRCA2 mutation carriers.
author: Garber, Judy E., Lynch, Henry T., Struewing, Jeffery P., Narod, Steven A., Neuhausen, Susan L., Stoppa-Lyonnet, Dominique, Nathanson, Katherine L., Antoniou, Antonis C., Sinilnikova, Olga M., Simard, Jacques, Leone, Melanie, Dumont, Martine, Barjhoux, Laure, Hughes, David J., Coupier, Isabelle, Belotti, Muriel, Lasset, Christine, Bonadona, Valerie, Bignon, Yves-Jean, Rebbeck, Timothy R., Wagner, Theresa, Domchek, Susan M., Weitzel, Jeffrey, Tomlinson, Gail, Godwin, Andrew
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Science & research, Risk factors, Polymerase chain reaction, Mutation (Biology), Mutation
subjects list: Research, Usage, Canada, Genetic aspects, Breast cancer, Chromosome mapping, Genetic disorders