Functional proteomics reveals the biochemical niche of C.elegans DCR-1 in multiple small-RNA-medicated pathways
Article Abstract:
A study was conducted to learn how C.elegans Dicer, DCR-1, functions in multiple distinct silencing mechanisms where a mass-spectrometry-based proteomics approach was used to identify DCR-1-interacting proteins. The findings provide a first glimpse at the complex biochemical nice of Dicer and suggests that competition exists between DCR-1-mediated small-RNA path-ways.
author: Ruvkun, Gary, Harding, Sandra, Kennedy, Scott, Mello, Craig C., Conte, Darryl, Jr., Brownell, Daniel R., Duchaine, Thomas F., Wohischiegel, James A., Bei Yanxia, Pang, KaMing, Mitani, Shohel
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Japan, Biological Product (except Diagnostic) Manufacturing, Drugs, Deoxyribonucleic Acid, DNA, Gene silencing, RNA interference
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
Article Abstract:
Research has been conducted on the gene silencing phenomenon RNAi which can be triggered by the double-stranded RNA. The inactivation of genes related to the RNAi pathway genes has been carried out and the heterochronic phenotypes produced by this inactivation have been examined and discussed.
author: Ruvkun, Gary, Pasquinelli, Amy E., Parrish, Susan, Fire, Andrew, Grishok, Alla, Conte, Darryl, Li, Na, Ilho Ha, Baillie, David L., Mello, Craig C.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
South Korea, Statistical Data Included, Phenotype, Phenotypes, Caenorhabditis elegans
A panoramic view of yeast noncoding RNA processing
Article Abstract:
Research has been conducted on yeast functional proteomics and genomics. The authors discuss the data revealing yeast noncoding RNA processing, and report that uncharacterized yeast proteins are involved in noncoding RNA biogenesis.
author: Cagney, Gerard, Hughes, Timothy R., Peng, Wen-Tao, Robinson, Mark D., Mnaimneh, Sanie, Krogan, Nevan J., Morris, Quaid, Davierwala, Armaity P., Grigull, Jorg, Yang, Xueqi, Zhang, Wen, Mitsakakis, Nicholas, Ryan, Owen W., Datta, Nira, Jojic, Vladimir, Pal, Chris, Canadien, Veronica, Richards, Dawn, Beattie, Bryan, Wu, Lani F., Altschuler, Steven J., Roweis, Sam, Frey, Brendan J., Emili, Andrew, Greenblatt, Jack F.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
Proteins, Yeast fungi, Yeasts (Fungi), Origin of life, Proteomics, Genomics
subjects list: Research, United States, Analysis, Canada, Physiological aspects, Genetic aspects, Gene expression, RNA, Cell research, Cytological research