ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons

Article Abstract:

Research has been conducted on motor behavior control. The effect of the motor-sensory neuron connections on the motor behavior is discussed.

United States, Statistical Data Included, Analysis, Cell research, Cytological research, Afferent pathways

A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity

Article Abstract:

The specification of motor neuron pool identity and connectivity by a Hox transcriptional regulatory network is shown. Two interdependent sets of Hox regulatory interactions form a network to operate within motor neurons, which establishes identity of motor neuron pools and defines the pattern of target-muscle connectivity.

Science & research

Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression

Article Abstract:

Members of the ETS class of transcription factors are expressed in a selective manner by motor neuron pools within the lateral motor column. It is shown that two ETS genes, PEA3 and ER81, define motor neuron pools at limb levels of the chick spinal cord. The expression of ETS genes by sensory and motor neurons is regulated by signals derived from the limb target. Thus, the selectivity of the connections formed between sensory and motor neurons in the developing spinal cord may be controlled by ETS gene expression.

Gene expression, Spinal cord