Genome-wide prediction of genetic interactions in a metazoan

Article Abstract:

Computational integration of multiple types of functional genomic data is used to generate genome-wide predictions of genetic interactions in Saccharomyces cerevisiae. The prediction for Caenorhabditis elegans is generated by computationally integrating functional genomic data from S. cerevisiae, C. elegans and Drosophila melanogaster, which is an important step toward system-level understanding of biological systems and human diseases.

Japan, Metazoa, Metazoans, Genomic imprinting

An inversion in the wiring of an intercellular signal: Evolution of Wnt signaling in the nematode vulva

Article Abstract:

Wnt signaling is recruited in four cell specification events during Caenorhabditis elegans vulva development including the activation of the vulval differentiation. Wnts act to repress vulval differentiation in the nematode Pristionchus pacificus, demonstrating evolutionary flexibility in the use of intercellular signaling pathways.

Cells (Biology), Vulva, Cells

Pristionchus pacificus: A well-rounded nematode

Article Abstract:

Nematodes pervade Earth's biosphere and occupy innumerable ecological niches. The role of Caenorhabditis elegans as a model for developmental processes has encouraged cultivating a second nematode, Pristionchus pacificus, as a comparative counterpoint to address questions in development, behavior and ecology in nematode evolution.

Environmental aspects, Nematoda, Nematodes