Global transcriptional regulation of the locus encoding the skeletal muscle determination genes Mrf4 and Myf5

Article Abstract:

A novel mechanism for the global transcriptional control of the locus encoding the skeletal muscle determination genes Mrf4 and Myf5 is discussed. The model includes transcription balancing sequences in a series of equilibria for ensured production of the highly dynamic and exquisitively specific expression patterns of the two genes.

Genetic aspects, Genetic transcription, Transcription (Genetics)

The initial somitic phase of Myf5 expression requires neither Shh signaling nor Gli regulation

Article Abstract:

A study is undertaken to demonstrate that activation of Myf5 expression depends on neither Shh function nor an intact Gli binding site. The findings indicate that the disagreement is due to the existence of specific interactions between the enhancer and the Myf5 promoter.

Genetic research, Somite, Somites (Embryology)

Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development

Article Abstract:

Gene amplification in house mouse and the role played by fibronectin leucine rich repeat transmembrane in regulating this process is examined.

United States, Biochemistry, Research and Development in the Physical, Engineering, and Life Sciences, Mice, Growth, Developmental biology, Protein binding, House mouse, Gene amplification, Company growth