IKKbeta links inflammation and tunorigenesis in a mouse model of colitis-associated cancer

Article Abstract:

A study is conducted to show that although deletion of IKKBeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size. A key player in inflammation is transcription factor NF-kB whose activity is triggered in response to infectious agents and proinflammatory cytokines via the IkB kinase (IKK) complex.

Analysis, Protein kinases, Cytokines, Tumor proteins, Tumour proteins

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

Article Abstract:

It is investigated whether I (sub k) B kinase beta (IKKbeta) is involved in chemically induced liver cancer, which is a model not involving overt inflammation. IKKbeta orchestrates inflammatory crosstalk between hepatocytes and hematopoietic-derived cells that promotes chemical hepatocarcinogenesis.

Liver cells, Hepatocytes, Carcinogenesis, Liver cancer, Genetic research

The E3 ubiquitin ligase itch couples JNK activation to TNF alpha-induced cell death by inducing c-FLIP turnover

Article Abstract:

The turnover of the NF-KB-induced antiapoptotic protein C-FLIP is accelerated by tumor necrosis factor (TNF) alpha-mediated Jun kinase (JNK) activation. JNK promotes the proteasomal elimination of c-FLIP and thus antagonizes NF-KB during TNF alpha signaling.

California, Physiological aspects, Cell death, Tumor necrosis factor, Rats, Ubiquitin, Properties, Rattus, Tumour necrosis factor