Lineage commitment in the immune system: the T helper lymphocyte grows up

Article Abstract:

The T helper lymphocytes and their function in the immune system are discussed in this review article. The current knowledge of signals that regulate lineage commitment in T helper cells is summarized with emphasis on three subset-specific transcription factors responsible for lineage commitment. They are T-bet, c-Maf and GATA-3. Topics include cytokines, development of the Th1 lineage and signaling pathways, interferons in the Th1 responses, APC, antigen and costimulation.

Physiological aspects, DNA, Chromatin, Developmental biology, Cellular signal transduction, Embryology, Experimental, Embryological research, Cell differentiation, T cells, Cytokines

PGC-1[alpha] regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy

Article Abstract:

The transcription of a neuromuscular junction gene is enhanced by the phosphorylation of PGC-1[alpha] and GA-binding protein. The control extended by the coactivator PGC-1[alpha] is found to be vital in the treatment of Duchenne muscular dystrophy.

Science & research, Care and treatment, Genetic aspects, Neuromuscular junction, Duchenne muscular dystrophy

Transcriptional regulation of adipogenesis

Article Abstract:

Research has been conducted on the molecular regulation of differentiation for specific cell types. The results of the experiments with the adipose tissue are described.

Statistical Data Included, Analysis, Adipose tissues, Adipose tissue, Fat cells, Adipocytes