Local spreading of MSL complexes from roX genes on the Drosophila X chromosome

Article Abstract:

Research has been conducted on MSL proteins and noncoding roX RNAs which up-regulate genes on the Drosophila male X chromosome. The authors describe the model of MSL complex distribution, and report that when overexpressed, MSL proteins can recognize X chromosome, partially restore male viability in the absense of roX RNAs and modify histones.

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Crystal structure of the Drosophila Mago nashi-Y14 complex

Article Abstract:

Research has been conducted on Drosophila Mago nashi-Y14 complex. The authors have investigated the structure of this complex in order to understant the structural basis of Mago nashi-Y14 interactions, and the structural analysis reveals the mode of this interaction via the RNA-binding surface of the Y14 recognition motif.

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Pre-mRNA splicing and human disease

Article Abstract:

The authors review the publications on human gene expression. The topics of interest include pre-mRNA constitutive splicing and basal slicing machinery, and the role of pre-mRNA splicing disruption in human diseases.

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