Methods of analysis and resources available for genetic trait mapping

Article Abstract:

There are several ways of carrying out genetic trait mapping. These methods determine the genetic distance between two loci on chromosome. Genetic markers are utilized to localize disease genes by linkage analysis. A critical component of a genetic marker is its heterozygosity that determines the proportion of individuals in a population who are heterozygous for that marker. A number of institutions offer free programs on genetic linkage analysis. In addition, there are also several books and Web sites on the subject.

author: Ott, J.

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A marker set for construction of a genetic map of the silver fox (Vulpes vulpes)

Article Abstract:

The genomic organizations of the silver fox (Vulpes vulpes) and the dog (Canis familiaris) are compared. Several single nucleotide polymorphisms (SNPs) are found when a sequence comparison of genes from tame and aggressive foxes is conducted. Canine genomic tools are utilized in developing a fox meiotic map and mapping behavioral traits in the fox due to a close relationship between the fox and dog.

author: Aguirre, G.D., Kukekova, A.V., Trut, L.N., Oskina, I.N., Kharlamova, A.V., Shikhevich, S.G., Kirkness, E.F., Achland, G.M.
Genetic polymorphisms, Red fox

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Individual DNA bands obtained by RAPD analysis of canine genomic DNA often contain multiple DNA sequences

Article Abstract:

A study was conducted to analyze DNA bands of dogs determined by the random amplified polymorphic DNA (RAPD) technique. A DNA template isolated from miniature poodles was utilized to carry out RAPD-polymerase chain reaction. Positive clones were then examined by restriction digestion. Experimental results indicated that RAPD bands amplified from the canine genome support more than one DNA fragment.

author: Aguirre, G.D., Ray, K., Gu, W., Post, C.M.
DNA

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subjects list: Research, Analysis, Genetic aspects, Genomes, Chromosome mapping, Dogs