Article Abstract:
The invariant chain (li) refers to a constant set of proteins associated with the major histocompatibility complex (MHC) class II molecules. No definitely proven functional role for li has been presented. To elucidate this problem, a mouse line containing a large deletion in the li gene, resulting in nonexpression of li, was developed. Characterization of this mouse line showed that li plays a role in the intracellular transport of MHC class II molecules. This mouse line will be useful in further analyses on the function of the invariant chain.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
A new mouse model of rheumatoid arthritis, KRNxNOD, has been developed and used to investigate the mechanism of pathogenesis. The model was generated by crossing a T cell receptor transgenic line with the NOD strain. Arthritis in KRNxNOD mice was found to share majority of the clinical, histological and immunological properties of the human disorder. Among the useful features of the KRNxNOD model are 100% disease incidence, early and reproducible time of onset and predictable disease progression.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
Mice without H2-M complexes were developed to study their importance in helping peptide insertion onto major histocompatibility complex (MHC) class II molecules. Cells from the altered mice produced very little MHC proteins. However, they were able to conduct positive selection of CD4+ T cells efficiently. Peripheral T cells interacted very avidly with splenocytes from syngeneic wild-type mice.
User Contributions:
Comment about this article or add new information about this topic: